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AME 50548 - Biofabrication

Description: This course covers materials processing and advanced manufacturing approaches as applied to biomedical science and engineering including photolithography, softlithography, AFM and SEM-based fabrication and 3D micro-nanofabrication for applications such as microfluidics; scaffold production for tissue engineering, studying mechanotransduction and the cellular forces, nanoparticles and nanoscale structures as functional bio-interfaces, peptide-nanoparticle assemblies, nanoparticle-biomolecule hybrids as bioactive materials, self-assembling peptides scaffolds for 3-dimensional tissue / cell cultures, magnetic cell separation to enrich for rare cells.

AME Concentrations that the course could be listed in:

Bioengineering

Design and Manufacturing

Materials

List of topics:

1) Introduction to microfabrication

2) Microscale modifications of materials for controlling cellular microenvironments

3) Microfabrication approaches for scaffold fabrication

4) Micromechanical control of cell-cell interactions and study of cellular forces

5) Microfabrication techniques for microfluidic devices

6) Lab-on-a-chip impedance detection of microbial and cellular activity

7) Human-on-chip modeling of drug metabolism

8) Introduction to nanofabrication

9) Nanoparticle functionalization with biomolecules for therapeutics and imaging agents

10) Nanoscale modifications of materials for controlling cellular microenvironments

11) Nanofabrication approaches for scaffold fabrication